Transcriptomic profiling of electrophysiologically characterized human iPSC-derived motor neurons having SOD1 A4V mutation

ABSTRACT: To find the molecular basis for abnormal excitability in human iPSC-derived motor neurons with the SOD1 A4V mutation and its involvement in risk of cell loss, we conducted a patch-seq, which combines genome-wide RNA sequencing and patch-clamp recording. This experiment enables excitability and gene expression to be measured simultaneously at a single cell level such that the links between the two could be explored.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138120 | GEO | 2023/10/01

REPOSITORIES: GEO