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Pathophysiological role of MIG-6 and ERBB2 in progesterone resistance and endometriosis-related infertility.

ABSTRACT: MIG-6 loss caused progesterone resistance through ERBB2 overexpression in non-receptive endometrium of endometriosis-related infertility. We used microarrays to understand the molecular mechanisms of progesterone resistance in infertility

ORGANISM(S): Mus musculus

PROVIDER: GSE138185 | GEO | 2019/11/30

REPOSITORIES: GEO

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Pathophysiological role of MIG-6 and ERBB2 in progesterone resistance and endometriosis-related infertility.

Project description:Pathophysiological role of MIG-6 and ERBB2 in progesterone resistance and endometriosis-related infertility.

| PRJNA575007 | ENA

RNA-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

Project description:We performed RNA-seq and ATAC-seq on in vitro activated P14 CD8 T cells transduced with MIG (empty), MIG-E47, or MIG-ID2.

2021-04-02 | GSE142343 | GEO

ATAC-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

Project description:We performed RNA-seq and ATAC-seq on in vitro activated P14 CD8 T cells transduced with MIG (empty), MIG-E47, or MIG-ID2.

2021-04-02 | GSE142342 | GEO

Krüppel-like Factor 9 and Progesterone Receptor Co-Regulation of Decidualizing Endometrial Stromal Cells: Implications for its Loss in the Pathogenesis of Endometriosis

Project description:Endometriosis is characterized by progesterone resistance and is associated with infertility. Krüppel-like Factor 9 (KLF9) is a progesterone receptor (PGR)-interacting protein, and mice null for Klf9 are subfertile. Whether loss of KLF9 contributes to progesterone resistance of eutopic endometrium of women with endometriosis is unclear. The aim of this study was to investigate KLF9 and PGR co-regulation of human endometrial stromal cell (HESC) transcriptome network.

2012-04-04 | GSE31683 | GEO

MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

Project description:MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

| PRJNA596670 | ENA

KrM-CM-<ppel-like Factor 9 and Progesterone Receptor Co-Regulation of Decidualizing Endometrial Stromal Cells: Implications for its Loss in the Pathogenesis of Endometriosis

Project description:Endometriosis is characterized by progesterone resistance and is associated with infertility. KrM-CM-<ppel-like Factor 9 (KLF9) is a progesterone receptor (PGR)-interacting protein, and mice null for Klf9 are subfertile. Whether loss of KLF9 contributes to progesterone resistance of eutopic endometrium of women with endometriosis is unclear. The aim of this study was to investigate KLF9 and PGR co-regulation of human endometrial stromal cell (HESC) transcriptome network. Microarray gene expression analysis was conducted in decidualizing HESC by silencing the expression of KLF9 and PGR, alone or in combination by a siRNA approach, to identify additional KLF9 and PGR co-regulated genes and signaling networks/pathways. HESC also treated with 8-bromo-cAMP, 17M-CM-^_-estradiol, and medroxyprogesterone acetate (cAME) to mimic stromal progression from a proliferative to a differentiated state.

2012-04-03 | E-GEOD-31683 | biostudies-arrayexpress

Macrophage migrasomes (M-mig) gene profiling

Project description:In the present study, we have documented a previously unrecognized membrane vesicles called “migrasomes” (M-mig) that originate from the filament-like nanotubes of macrophage.To characterize the signatures of macrophage migrasomes (M-mig) gene expression that might underlie M-mig-associated biological function. M0-mig, M1-mig, M2-mig and HG-mig genome-wide expression profiling was carried out by using SurePrint G3 Mouse GE V2.0 8X60K Microarrays (Design ID:074809, Agilent Technologies, USA). Total RNA was quantified by the NanoDrop ND-2000 (Thermo Scientific) and the RNA integrity was assessed using Agilent Bioanalyzer 2100 (Agilent Technologies). The sample labeling, microarray hybridization and washing were performed based on the manufacturer’s standard protocols. Briefly, total RNA was transcribed to double strand cDNA, then synthesized into cRNA and labeled with Cyanine-3-CTP. The labeled cRNAs were hybridized onto the microarray. After washing, the arrays were scanned by the Agilent Scanner G2505C (Agilent Technologies). For data analysis, Feature Extraction software (version10.7.1.1, Agilent Technologies) was used to analyze array images to get raw data. Genespring (version14.9, Agilent Technologies) were employed to finish the basic analysis with the raw data. To begin with, the raw data was normalized with the quantile algorithm. Differentially expressed genes were then identified through fold change. The threshold set for up- and down-regulated genes was a fold change>=2.0. Afterwards, GO analysis and KEGG analysis were applied to determine the roles of these differentially expressed mRNAs.

2022-05-06 | E-MTAB-7994 | biostudies-arrayexpress

RNA-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

Project description:RNA-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

| PRJNA596673 | ENA

ATAC-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

Project description:ATAC-seq of MIG, MIG-E47, or MIG-ID2 transduced CD8 T cells in vitro

| PRJNA596674 | ENA

Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.

Project description:The disruption of cholesterol homeostasis leads to an increase in cholesterol levels which results in the development of cardiovascular disease. Mitogen Inducible Gene 6 (Mig-6) is an immediate early response gene that can be induced by various mitogens, stresses, and hormones. To identify the metabolic role of Mig-6 in the liver, we conditionally ablated Mig-6 in the liver using the Albumin-Cre mouse model (Albcre/+Mig-6f/f; Mig-6d/d). Mig-6d/d mice exhibit hepatomegaly and fatty liver. Serum levels of total, LDL, and HDL cholesterol and hepatic lipid were significantly increased in the Mig-6d/d mice. The daily excretion of fecal bile acids was significantly decreased in the Mig-6d/d mice. DNA microarray analysis of mRNA isolated from the livers of these mice showed alterations in genes that regulate lipid metabolism, bile acid, and cholesterol synthesis, while the expression of genes that regulate biliary excretion of bile acid and triglyceride synthesis showed no difference in the Mig-6d/d mice compared to Mig-6f/f controls. These results indicate that Mig-6 plays an important role in cholesterol homeostasis and bile acid synthesis. Mice with liver specific conditional ablation of Mig-6 develop hepatomegaly and increased intrahepatic lipid and provide a novel model system to investigate the genetic and molecular events involved in the regulation of cholesterol homeostasis and bile acid synthesis. Defining the molecular mechanisms by which Mig-6 regulates cholesterol homeostasis will provide new insights into the development of more effective ways for the treatment and prevention of cardiovascular disease.

2011-08-31 | GSE31752 | GEO

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