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NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_1

ABSTRACT: We report the genome wide occupancy of p65, H3K4Me3, H3K27Ac and p300 in MCF7-NAIL-WT and MCF7-NAIL-ΔNFκB cells stimulated with TNF alpha for 0min, 45min and 90 min.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138308 | GEO | 2023/09/01

REPOSITORIES: GEO

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NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_3

Project description:We report the differential gene expression analysis in MCF7-NAILWT and MCF7-NAILΔNFκB cells stimulated with TNF alpha for 0min, 45min and 90 min.

2023-09-01 | GSE138237 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

Project description:We report the differential gene expression analysis of lncRNAs in wild-type, p65 KO and IKK2 KO MEFs stimulated with TNF alpha for 0min, 45min and 90 min.

2020-11-01 | GSE157476 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

Project description:We report the differential gene expression analysis of DSS treated colon tissues obtained from WT and NAIL-ΔNFκB mouse.

2020-11-01 | GSE138235 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-02 | GSE138310 | GEO

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_4

| PRJNA661450 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation

| PRJNA575378 | ENA

NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

Project description:NAIL: an evolutionarily conserved lncRNA essential for coordinating p38 activation and NFκB mediated chromatin remodelling in inflammation_2

| PRJNA575183 | ENA

<i>NAIL</i>: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis.

Project description: Not available

| S-EPMC8458091 | biostudies-literature

Expression analysis of nail matrix in mouse.

Project description:Mammalian digit-tip can regenerate upon amputation1-3, like amphibians. It is unknown why this capacity is limited to the area associated with the nail3-5. Here, we show that nail stem cells (NSCs) reside in the Wnt-suppressed proximal nail matrix and that the mechanisms governing NSC differentiation are directly coupled with their ability of orchestrating digit regeneration. Early nail progenitors located distal to the NCS region undergo Wnt-dependent differentiation into nail. Upon amputation, this Wnt activation is required for nail regeneration and also for attracting nerves that promote mesenchymal blastema growth, leading to regeneration of the entire digit. Amputations proximal to the Wnt-active nail progenitors result in failure to regenerate nail/digit. Nevertheless, Î²-catenin stabilization in the NSC region induced their regeneration. These results establish a link between NCS differentiation and digit regeneration, suggesting a utility of the NSCs in developing novel treatments for amputees. Nail matrix cells were harvested from proximal and distal matrix region by microdissection and processed to RNA extraction and hybridization on Affymetrix microarrays. We analyzed two proximal and two distal matrix cells.

2013-03-27 | E-GEOD-45494 | biostudies-arrayexpress

Single cell RNAseq of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium

Project description:Here, we studied transcriptome profiles of human nail units from polydactly samples. Single cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations

2021-06-15 | GSE158970 | GEO

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