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Expression data of J3T-1, J3T-2, J3T-1shA, J3T-2A glioma

ABSTRACT: We have previously established two sibling glioma subclones, J3T-1 and J3T-2, showing distinct invasive and angiogenic phenotypes. J3T-1, expressing high annexin A2, demonstrates robust angiogenesis and tumor invasion around neovasculature. J3T-2, expressing low annexin A2, demonstrates diffuse invasion along white matter tracts. Knockdown of annexin A2 in J3T-1 (J3T-1shA) resulted in diffuse invasion pattern, and overexpression of annexin A2 in J3T-2 (J3T-2A) showed prominent angiogenesis. We used microarrays to identify genes which promote the phenotypic transition regulated by annexin A2.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE138374 | GEO | 2020/04/20

REPOSITORIES: GEO

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