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ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin-STAG1 from WAPL

ABSTRACT: The human genome folds to create thousands of loops connecting sites that are bound by the insulator protein CTCF and the ring-shaped cohesin complex. It is thought that most of these loops emerge through a process whereby cohesin extrudes chromatin, forming an initially small loop that grows larger and larger until the loop’s expansion is arrested by CTCF. Cohesin rings comprise four proteins: SMC1, SMC3, SCC1, and, in higher eukaryotes, either STAG1 or STAG2. We explore differential roles of especially STAG1, STAG2 and ESCO1 proteins in chromatin organization.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138405 | GEO | 2020/02/27

REPOSITORIES: GEO

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Response of cohesin STAG1 and STAG2 to reduction of NIPBL levels [Hi-C]

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