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Quantitative analysis of transcriptomes in control and mTORC2-suppressed glioblastoma cells

ABSTRACT: We herein demonstrate that mammalian target of rapamycin complex 2 (mTORC2), a critical core component of the growth factor signaling system, globally alters histone modification as well as transcriptome through metabolic reprogramming in the highly malignant brain tumor glioblastoma (GBM). Integrated analyses unravel that mTORC2 regulates mineral metabolism including iron trafficking via histone H3K9 acetylation of the ferritin promoter, facilitating GBM growth and survival.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138475 | GEO | 2019/11/07

REPOSITORIES: GEO

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Genome-wide maps of chromatin H3K9ac state in control and mTORC2-suppressed glioblastoma cells

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