Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Global survey of miRNA microarray of whole embryo, wild type vs estrogen receptor alpha knockout mice

ABSTRACT: To examine the effect of estrogen receptor alpha for the miRNA expression, total RNA extracted from whole embryos at E18.5 of wild type and Estrogen Receptor alpha knock-out mice

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE13859 | GEO | 2009/07/22

SECONDARY ACCESSION(S): PRJNA114583

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Global survey of miRNA microarray of whole embryo, wild type vs estrogen receptor alpha knockout mice

Project description:To examine the effect of estrogen receptor alpha for the miRNA expression, total RNA extracted from whole embryos at E18.5 of wild type and Estrogen Receptor alpha knock-out mice Two group experiment (wild type and ER alpha KO)

2010-06-24 | E-GEOD-13859 | biostudies-arrayexpress

Global survey of miRNA Taqman RT-PCR of whole embryo: wild-type vs. estrogen receptor alpha knockout mice

2009-07-22 | GSE16513 | GEO

Global survey of miRNA Taqman RT-PCR of whole embryo: wild-type vs. estrogen receptor alpha knockout mice

2009-07-22 | E-GEOD-16513 | biostudies-arrayexpress

Global survey of miRNA profiles in the uterus and an estrogen receptor alpha knockout embryo

Project description:This SuperSeries is composed of the following subset Series: GSE13858: Global survey of miRNA microarray of uterus, ovariectomized female mice with or without estrogen (E2) treatment GSE13859: Global survey of miRNA microarray of whole embryo, wild type vs estrogen receptor alpha knockout mice Refer to individual Series

2010-06-24 | E-GEOD-14031 | biostudies-arrayexpress

Network and pathway microarray expression analysis of cardiac-specific estrogen receptor alpha knockout mice

Project description:Analysis of estrogen receptor alpha function in the heart at gene expression level. The hypothesis tested in the present study was that absence of estrogen receptor alpha may induce cardiometabolic alterations. Results provide information of the responses to the absence of Estrogen receptor alpha such as core pathways that are affected, up- or down-regulated specific metabolic functions.

2016-08-12 | GSE55936 | GEO

Estrogen Receptor-α knockout females, but not Estrogen Receptor-β knockout females, show male-specific liver gene expression

Project description:Estrogen protects females from hepatocellular carcinoma (HCC). To determine whether this protection is mediated by classic estrogen receptors, we tested HCC susceptibility in estrogen receptor-deficient mice. In contrast to a previous study, we found that diethylnitrosamine induces hepatocarcinogenesis to a much greater extent when females lack Esr1, which encodes Estrogen Receptor-α. Relative to wild-type littermates, Esr1 knockout females developed 9-fold more tumors. Deficiency of Esr2, which encodes Estrogen Receptor-β, did not affect liver carcinogenesis in females. Using microarrays and QPCR to examine estrogen receptor effects on hepatic gene expression patterns, we found that germline Esr1 deficiency resulted in the masculinization of gene expression in the female liver.

2021-02-28 | GSE164900 | GEO

Estrogen Receptor-α knockout females, but not Estrogen Receptor-β knockout females, show male-specific liver gene expression

Project description:Estrogen Receptor-α knockout females, but not Estrogen Receptor-β knockout females, show male-specific liver gene expression

| PRJNA692428 | ENA

Nuclear Estrogen Receptor alpha (ERα) interactome following estrogen and antiestrogen treatment.

Project description:The Estrogen Receptor alpha (ERα) controls key cellular functions in hormone responsive breast cancer by assembling in large functional multiprotein complexes. ERα ligands are classified as agonists and antagonist, according to the response they elicit, thus the molecular characterization of the of ERα nuclear iteractome composition following estrogen and antiestrogen stimulation whose is needed to understand their effects on estrogen target tissues, in particular breast cancer. To this aim interaction proteomics coupled to mass spectrometry (MS) was applied to map the ERα nuclear interacting partners in MCF7 breast cancer cell nuclei following estrogen and antiestrogen stimuli.

2020-09-02 | PXD018709 | Pride

An Estrogen Receptor α-bound Human Chromatin Interactome

Project description:We developed Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) for de novo detection of global chromatin interactions, and comprehensively mapped the chromatin interaction network bound by estrogen receptor α (ERα) in the human genome. We performed 454 and Illumina sequencing analyses. Keywords: Epigenetics Using 454, we examined 3 libraries: IHM001 (Estrogen Receptor ChIA-PET), IHM043 (Estrogen Receptor ChIP-PET) and IHM062 (IgG ChIA-PET) Using Illumina, we examined 4 libraries: IHM001 (Estrogen Receptor ChIA-PET replicate 1, Paired End Sequencing), IHH015 (Estrogen Receptor ChIA-PET replicate 2, Paired End Sequencing), H3K4me3 ChIP-Seq and RNA polymerase II ChIP-Seq

2009-09-11 | E-GEOD-18046 | biostudies-arrayexpress

Genome-wide Estrogen Receptor-alpha activation time-course

Project description:Genome-wide Estrogen Receptor-alpha activation time-course

| PRJNA487952 | ENA