RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.

ABSTRACT: • IGF2BP1 promotes leukemia stem cell phenotype by regulating HOXB4, MYB and ALDH1A1.• Inhibition of IGF2BP1 reduces leukemia tumorigenicity, and enhances leukemia cell death and differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138704 | GEO | 2020/02/10

REPOSITORIES: GEO