Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.

ABSTRACT: Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated reduction of mTORC1 signaling, aerobic respiration and expression of genes involved in ribosome biogenesis.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE138729 | GEO | 2019/10/11

REPOSITORIES: GEO