Overexpression of homeobox gene DLX1 unravels a novel mechanism in driving prostate cancer

ABSTRACT: Higher expression levels of DLX1 has been associated with primary and metastatic prostate tumor. DLX1 along with HOXC6 is well-established diagnostic biomarker for the early detection of prostate cancer (PCa). However, the mechanism involved in DLX1 up-regulation and functional significance in metastatic castration-resistant prostate cancer (mCRPC) progression remains unexplored. Here, we identified that DLX1 serves as an oncogene thereby regulating several oncogenic properties associated with PCa progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138738 | GEO | 2021/07/30

REPOSITORIES: GEO