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MRNAs and LncRNA microarray of HBE cell exposed to Al2O3 NPs, PM2.5, DEP

ABSTRACT: mRNAs and LncRNAs have been implicated in the regulation of a board range of biological processes including development, immunity and inflammation We used mRNA and LncRNA microarray to explore the detailed biological processes and mechanisms underlying matter-induced pulmonary toxicity

ORGANISM(S): Homo sapiens

PROVIDER: GSE138870 | GEO | 2021/09/15

REPOSITORIES: GEO

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MicroRNA microarray of HBE cell exposed to Al2O3 NPs, PM2.5, DEP

Project description:miRNAs have been implicated in the regulation of a broad range of biological processes including development, immunity and inflammation We used miRNA microarray to explore the detailed biological processes and mechanisms underlying matter-induced pulmonary toxicity

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mRNAs and LncRNA microarray of HBE cell exposed to Al2O3 NPs, PM2.5, DEP

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Diesel exhaust particle (DEP)-treated HBE cells

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Project description:Several epidemiological pieces of evidence on air pollution health effects have notably accelerated in recent years. They have described the relationship between PM2.5 (ambient fine particulate matter of <2.5 μm in diameter) and kidney diseases. Previous research has shown that lactoferrin showed renoprotective effects against some kidney diseases. In the current study, we analyzed the transcriptional profiles of PM2.5 and lactoferrin using RNA sequencing (RNA-seq) and identified the key signaling pathway in the human kidney proximal tubular epithelial cell line (HK-2 cells).

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