β-catenin regulates FOXP2 transcriptional activity via multiple binding sites

ABSTRACT: We observed different gene expression by overexpressing the transcription factor FOXP2 in U2OS cells compared to mock-transfected cells. Additionally, we found β-catenin as co-activator binding directly to FOXP2. Activation of Wnt signaling was changing the transcriptional activity of FOXP2. Other functional and regulatory elements were found within FOXP2 and were confirmed by RNA-Seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138938 | GEO | 2020/06/01

REPOSITORIES: GEO