Epigenome analysis of statin-treated SGBS pre-adipocytes during differentiation

ABSTRACT: We investigated the role of statin treatment in adipocyte differentiation by using the in vitro pre-adipocyte SGBS cell line. We found that statins induced a reduction in adipogenesis by decreasing the mRNA expression of key transcriptional regulators, such as ADIPOQ and GLUT4. Therefore, we analysed the whole methylome of statin-treated cells, compared to DMSO-vehicle controls, using the 850K methylation arrays (Illumina) to identify putative effective genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139211 | GEO | 2020/09/21

REPOSITORIES: GEO