Single-cell, multi-omic analysis identifies regulatory programs in mixed phenotype acute leukemia

ABSTRACT: We present a single-cell framework that integrates highly multiplexed protein quantification, transcriptome profiling, and chromatin accessibility analysis. Using this approach, we establish a normal epigenetic baseline for healthy blood development, which we then use to deconvolve aberrant molecular features within blood from mixed-phenotype acute leukemia (MPAL) patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139369 | GEO | 2019/10/25

REPOSITORIES: GEO