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ScRNA-seq reveals development of a broad spectrum of cell types in human iPSC derived hepatic organoids (HOs) and defines biomarkers in iPSC to liver lineage differentiation stages

ABSTRACT: At each differentiation stage, HO cultures contain different types of cells, and sub-populations of each cell type can be in various stages of differentiation; which makes it very difficult to identify critical transcriptional changes through analyses performed on the bulk population. To deal with the cellular complexity within dynamically changing organoid cultures at different developmental stages, single cell RNA sequencing (scRNA-Seq) can be used to simultaneously analyze global changes in the transcriptome of many individual cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139382 | GEO | 2019/10/26

REPOSITORIES: GEO

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scRNA-seq reveals development of a broad spectrum of cell types in human iPSC derived hepatic organoids (HOs) and defines biomarkers in iPSC to liver lineage differentiation stages

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