DNA methylation and gene expression changes during acquired resistance to ALK inhibitors (450k DNA methylation microarray)

ABSTRACT: To identify novel mechanisms of acquired resistance to ALK inhibitors, we established in vitro models of acquired resistance to ceritinib using H3122 cell. In this study, we examined genome-wide DNA methylation changes during acquired resistance to ceritinib. We also examined the heterogeneity of parental and resistant cells using single cell RNA--seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139387 | GEO | 2022/09/20

REPOSITORIES: GEO