Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA microarray in the synovial tissue 14 days after anterior cruciate ligament transection (ACLT)

ABSTRACT: To investigate changes in miRNA expression in the synovial tissue, miRNA microarray was performed at day 14 after ACLT and revealed that several miRNA expressions were changed more than 1.5-fold. We chose to analyze the role of miR-21 in joint pain after ACLT because it had the highest signal intensity among the increased miRNAs. Quantitative PCR confirmed that miR-21 expression in synovial tissue was significantly increased 14 days after ACLT.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE139532 | GEO | 2019/10/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

miRNA microarray in the synovial tissue 14 days after anterior cruciate ligament transection (ACLT)

Project description:miRNA microarray in the synovial tissue 14 days after anterior cruciate ligament transection (ACLT)

| PRJNA580191 | ENA

Muscle wasting in osteoarthritis model induced by anterior cruciate ligament transection.

Project description: Not available

| S-EPMC5927423 | biostudies-literature

RNA-sequencing from inflamed and normal synovial membrane after anterior cruciate ligament and/or meniscus injuries

Project description:Despite ample evidence demonstrating that anterior cruciate ligament (ACL) and meniscus tears are associated with the development of knee osteoarthritis (OA), the contributing factors remain unknown. Synovial inflammation has recently been recognized as a pivotal factor in the pathogenesis of OA. However, there is a lack of data on synovial profiles after ACL or meniscus injuries, which may contribute to posttraumatic OA (PTOA). We performed RNA-seq of 3 inflamed synovial biopsy samples vs 3 normal synovial biopsy samples following ACL and/or meniscus injuries. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and protein–protein interaction (PPI) analyses were performed to investigate mRNAs with significant differences between the inflamed and normal groups.Next, competing endogenous RNA (ceRNA) networks were constructed based on bioinformatics analyses and quantitative real-time polymerase chain reaction (RT–PCR) results. The association of the identified DEGs with the levels of infiltrating immune cells was explored using Pearson correlation analysis in R software. We aimed to provide greater insights into molecular mechanisms and biologic pathways in synovitis that could regulate post-trauma osteoarthritis progression.

2022-11-18 | GSE213070 | GEO

Anterior cruciate ligament reconstruction with preservation of femoral anterior cruciate ligament stump.

Project description: Not available

| S-EPMC4246405 | biostudies-literature

The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection.

Project description: Not available

| S-EPMC3510334 | biostudies-literature

Nanoscopic-Assisted Anterior Cruciate Ligament-Posterior Cruciate Ligament Reconstruction.

Project description: Not available

| S-EPMC8322670 | biostudies-literature

Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury

Project description:Identification of novel synovial fluid biomarkers that can differentiate early changes following ACL injury from OA using tandem-mass-spectrometry

2019-03-11 | MSV000083551 | MassIVE

Bone-Tendon-Autograft Anterior Cruciate Ligament Reconstruction: A New Anterior Cruciate Ligament Graft Option.

Project description: Not available

| S-EPMC7587499 | biostudies-literature

24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats.

Project description: Not available

| S-EPMC5019362 | biostudies-literature

Combined Double-Bundle Anterior Cruciate Ligament Reconstruction and Anterior Cruciate Ligament-Mimicking Anterolateral Structure Reconstruction.

Project description: Not available

| S-EPMC7451438 | biostudies-literature