Investigating the role of Foxp1 in murine A20 lymphoma cells

ABSTRACT: Purpose: to investigate the role of transcription factor Foxp1 in murine A20 lymphoma cells, which can be used as a model for human diffuse large B cell lymphoma Method: Exons 6 and 7 of Foxp1 were independently targeted using CRISPR/Cas9 editing, and 2 clones from each targeted exon (E6 and E7), showing depleted Foxp1 isoforms were isolated. Method: RNA sequencing was conducted on parental A20 cells and CRISPR clones, and differential gene expression was undertaken

ORGANISM(S): Mus musculus

PROVIDER: GSE139536 | GEO | 2020/04/03

REPOSITORIES: GEO