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Peripheral clonal expansion of T lymphocytes associates with tumour infiltration and response to cancer immunotherapy

ABSTRACT: We performed single-cell RNA sequencing (scRNA-seq) and deep analysis of T cell receptor (TCR) clonotypes (scTCR-seq) in cancer patients across several indications, assessing the profiles of TCRs in the various populations of T cells in tumours, normal adjacent tissue (NAT), and peripheral blood. In a subset of patients, we find clear evidence of clonotypic expansion of T effector-like cells not only within the tumour but also in NAT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE139555 | GEO | 2019/12/09

REPOSITORIES: GEO

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Peripheral clonal expansion of T cells (scRNA-seq)

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