Next-generation sequencing facilitates quantitative analysis of wild type and diabetic db/db mice islets transcriptomes

ABSTRACT: Long non-coding RNAs (LncRNAs) constitute an extensive fraction of the mammalian transcriptome. In this study, lncRNAs dysregulated in the islets of diabetic db/db mice were identified by high-throughput RNA sequencing. More than 1600 lncRNAs were detected using RNA sequencing, indicating that lncRNAs were abundant in islets. Among them, we found that lncRNA-Malat1 was significantly reduced in diabetic mouse islets. Further experiments suggested an involvement of lncRNA-Malat1 in lipotoxicity-induced β-cell dysfunction.

ORGANISM(S): Mus musculus

PROVIDER: GSE139823 | GEO | 2022/11/01

REPOSITORIES: GEO