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GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment [RNA-Seq]

ABSTRACT: The purpose of our study was to examine the role of GCN2 in the function of immunosuppressive cells such as tumor associated macrophages and MDSCs. We show that a myeloid lineage specific deletion of GCN2 results in a shift towards a more proinflammatory phenotype of tumor associated macrophages and MDSCs, thereby promoting anti-tumor immunity.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE140026 | GEO | 2020/03/10

REPOSITORIES: GEO

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