Transcriptomics

Dataset Information

17

Gene expression analysis of delg_mut versus Df_plus control


ABSTRACT: Nuclear transcription factors drive mitochondrial mass by regulating the expression of genes encoding mitochondrial proteins. Among these factors, nuclear respiratory factor 2 (NRF-2/GABP) has been proposed to be critical for mitochondrial mass in mammalian cells, yet there is little genetic evidence to support this function in vivo. Here, we show that mutants of the Drosophila melanogaster NRF-2alpha/GABPalpha homologue Delg (CG6338) have reduced expression of multiple genes encoding mitochondrial proteins, leading to reduced mitochondrial mass. Overall design: Six samples were analyzed in total: three biological replicates of the control (Df_plus) and three biological replicates of the mutant (Df_delg).

REANALYSED by: GSE119128

INSTRUMENT(S): [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Claudia Baltzer  

PROVIDER: GSE14058 | GEO | 2009-02-09

SECONDARY ACCESSION(S): PRJNA112423

REPOSITORIES: GEO

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