Transcriptomics

Dataset Information

28

Gene expression analysis of delg_mut versus Df_plus control


ABSTRACT: Nuclear transcription factors drive mitochondrial mass by regulating the expression of genes encoding mitochondrial proteins. Among these factors, nuclear respiratory factor 2 (NRF-2/GABP) has been proposed to be critical for mitochondrial mass in mammalian cells, yet there is little genetic evidence to support this function in vivo. Here, we show that mutants of the Drosophila melanogaster NRF-2alpha/GABPalpha homologue Delg (CG6338) have reduced expression of multiple genes encoding mitochondrial proteins, leading to reduced mitochondrial mass. Overall design: Six samples were analyzed in total: three biological replicates of the control (Df_plus) and three biological replicates of the mutant (Df_delg).

REANALYSED by: GSE119128

INSTRUMENT(S): [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Claudia Baltzer   

PROVIDER: GSE14058 | GEO | 2009-02-09

SECONDARY ACCESSION(S): PRJNA112423

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2015-08-28 | E-GEOD-14058 | ArrayExpress
2015-08-28 | E-GEOD-14058 | ExpressionAtlas
2011-12-06 | E-CBIL-28 | ArrayExpress
2010-04-14 | GSE21340 | GEO
2014-05-01 | E-GEOD-21340 | ArrayExpress
2009-07-15 | GSE16067 | GEO
2014-06-02 | E-GEOD-16067 | ArrayExpress
2008-09-03 | GSE12643 | GEO
2009-02-13 | GSE14780 | GEO
2014-05-04 | E-GEOD-14780 | ArrayExpress