Mutual dependency between a lncRNA and NPM1 is crucial for tumor cell proliferation

ABSTRACT: Silencing LETN or NPM1 in hepatocellular carcinoma cells inhibited cell proliferation and resulted in identical phenotypes. RNA-seq further revealed that knock-down of lncRNA LETN and NPM1 resulted in similar shifts of the gene expression profiles. This lncRNA-protein axis therefore plays indispensable roles in highly proliferative cells including a multitude of cancer cells and human neuronal precursor cells. Here we provide processed raw counts files.

ORGANISM(S): Homo sapiens

PROVIDER: GSE140708 | GEO | 2021/06/09

REPOSITORIES: GEO