Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Clp1 knockdown lentigenic mouse generation

ABSTRACT: Clp1 promotes 3’UTR shortening and higher levels of Aire-upregulated transcripts in mTEChi

ORGANISM(S): Mus musculus

PROVIDER: GSE140878 | GEO | 2020/05/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNAseq profiling of Ctr and CLP1 knockdown HEK293 cells

Project description:CLP1 promotes 3’UTR shortening and higher expression at Aire-sensitive genes in HEK293 cells

2020-05-05 | GSE140993 | GEO

Clp1 knockdown lentigenic mouse generation

Project description:Clp1 knockdown lentigenic mouse generation

| PRJNA591193 | ENA

WT and Aire-KO mouse MEChi RNAseq profiling

Project description:Aire-sensitive genes exhibit short 3'UTR transcript isoform preference in WT and Aire-KO mTEChi

2020-05-05 | GSE140683 | GEO

shRNA screen of factors involved in Aire-sensitive gene expression on their 3'UTR lengthening

Project description:CLP1 controls the expression of Aire-sensitive genes with proximal pAs and their shortening in HEK293 cells

2020-05-05 | GSE141118 | GEO

Stability of Aire-upregulated and Aire-neutral transcripts in medullary thymic epithelial cells

Project description:Aire-upregulated transcripts exhibit higher stability than the transcripts neutral to Aire's action in mTEChi

2020-05-05 | GSE140815 | GEO

The Cdc14 phosphatase, Clp1, does not affect genome expression

Project description:Schizosaccharomyces pombe Clp1 is a Cdc14-family phosphatase that reverses mitotic Cdk1 phosphorylation. Despite evolutionary conservation, Clp1’s mammalian orthologs do not share this function. Rather, higher eukaryotic Cdc14 enzymes act in DNA repair, ciliogenesis, and gene regulation. To examine if Clp1 regulates gene expression, we compared the transcriptional profiles of cells lacking Clp1 function to that of wildtype. Because clp1∆ cells are sensitive to the actin depolymerizing drug, LatrunculinA, we also investigated whether a transcriptional response was involved. Our results indicate that Clp1 does not detectably affect gene expression and highlight the organism-specific functions of this conserved phosphatase family.

2024-03-11 | GSE255124 | GEO

APS1 and celiac patients reveal autoimmune amelogenesis imperfecta

Project description:To investigate the dependence of amelogenesis imperfecta-related gene expression and ameloblast-related gene expression on Aire in the thymus, mTEChi from Aire+/+ and Aire-/- were sorted and subjected to bulk RNAseq.

2023-09-21 | GSE224247 | GEO

Effect of clp1 induction on rbf1-dependent gene regulation

Project description:The clp1 gene is a b-regulated gene that is required for clamp formation during the biotrophic growth phase of U. maydis. Interaction studies demonstrated that Clp1 imnteracts with Rbf1, the central regulator of pathogenciity. To exclude b-dependent effects the experiments were performed in a b-null background to analyze clp1-depndent effects on rbf controlled gene regulation

2010-09-17 | GSE21121 | GEO

Genomewide Analysis of Clp1 Function in Transcription in Budding Yeast

Project description:We report the GRO-Seq analysis in Clp1 mutant and the isogenic wild type strain to determine the the role of Clp1 in termination of transcription on a genomewide scale.

2017-07-31 | GSE71624 | GEO

Effect of clp1 induction on b-dependent gene regulation

Project description:The clp1 gene is a b-regulated gene that is required for clamp formation during the biotrophic growth phase of U. maydis. Clp1 expression blocks b-dependent filament formation and cell cycle arrest if co-induced with the b-heterodimer.

2011-03-30 | GSE21119 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data