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Transcriptome analysis of human colonic IgA+ plasma cell subsets and naïve B cells

ABSTRACT: Immunoglobulin A (IgA) is the most abundant antibody in the intestinal tract. Recent studies show that discrete subsets of gut human plasma cells (PCs) release IgA, which contributes to the maintenance of gut homeostasis. To better characterize the properties of these PC subsets, we performed global transcriptome analysis in naïve B cells as well as immature CD19+IgA+CD138- PCs, mature CD19+IgA+CD138+ PCs and late CD19-IgA+CD138+ PCs after their purification from human colon samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141005 | GEO | 2020/03/29

REPOSITORIES: GEO

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B cell residency but not T cell-independent IgA switching in the gut requires innate lymphoid cells

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Gene Expression Profiling Reveals Biological Insights into the Pathophysiology of Waldenströms macroglobulinemia

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Network analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity

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