Effect of metformin on chromatin accessibility in lung cancer cells

ABSTRACT: The DNA regions whose chromatin accessibility was significantly altered by metformin were investigated in lung cancer cells by ATAC-seq. Metformin decreased chromatin accessibility in 159 regions but increased it in 124 sites. Most regions were outside of gene promoters defined as TSS ± 3kb. The most suppressed region was 4,667bp downstream of CHAC1, and the most enhanced site was 15,111bp downstream of ERRFI1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141059 | GEO | 2019/11/27

REPOSITORIES: GEO