Transcriptomic profiling of small intestinal crypts upon MEX3A deletion

ABSTRACT: The effort to better understand intestinal stem cell (ISC) identity and regulation remains a challenge. We have been studying the RNA-binding protein MEX3A as a putative ISC marker. In that context, we have generated the first Mex3a knockout (KO) mouse model and show MEX3A is crucial for maintenance of the Lgr5+ ISC pool. As part of a phenotypic characterization pipeline, we have performed transcriptomic profiling (RNA-sequencing) of isolated Mex3a KO small intestinal crypts and compared it against small intestinal crypts isolated from age-matched wild-type controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE141191 | GEO | 2020/02/13

REPOSITORIES: GEO