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Differential Regulation of Alcohol Consumption and Reward by the Transcription Cofactor LMO4

ABSTRACT: The goal of this study is to identify and validate transcriptional targets of LMO4 in the Basolateral Amygdala (BLA) and the Nucleus Accumbens (NAc) We mapped about 15-25 million reads per sample to the mouse genome (mm9) . We identified about 16,000 transcripts per sample.

ORGANISM(S): Mus musculus

PROVIDER: GSE141312 | GEO | 2020/02/29

REPOSITORIES: GEO

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Differential Regulation of Alcohol Consumption and Reward by the Transcription Cofactor LMO4

Project description:Differential Regulation of Alcohol Consumption and Reward by the Transcription Cofactor LMO4

| PRJNA593033 | ENA

Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4.

Project description: Not available

| S-EPMC7558853 | biostudies-literature

A Circult Mechanism for Differentiating Positive and Negative Associations

Project description:The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Different neuronal populations of the basolateral amygdala complex (BLA) encode fearful or rewarding associations, but the molecular identity of these functionally distinct populations of BLA neurons remained unknown. Here, we show that BLA neurons projecting to the nucleus accumbens (NAc-projectors) or the centromedial amygdala (CeM-projectors) underwent opposing synaptic changes following fear or reward conditioning. The photostimulation of NAc projectors supported positive reinforcement while photostimulation of CeM projectors mediated negative reinforcement. In search of defining molecular characteristics of these functionally-distinct BLA neuronal populations, we compared gene expression profiles of NAc- and CeM-projectors.

2015-02-27 | GSE66345 | GEO

Developmentally regulated sex differences in K48 polyubiquitination in the amygdala

Project description:This project examined if sex differences in K48 polyubiquitination in the amygdala were developmentally regulated. This used basolateral amygdala (BLA) samples collected from 4 and 9 week old male and female Sprague-Dawley rats.

2023-11-06 | PXD042021 | Pride

Molecular Neurobiology of Loss Part 2

Project description:Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings of loss are poorly understood, making it challenging to develop treatment strategies. Here, we investigate the mechanisms of loss using an enrichment removal (ER) paradigm in rats. RNA-seq was used to investigate the molecular landscape of the basolateral amygdala (BLA), a region previously implicated in loss, in adult male Sprague-Dawley rats following ER. Rats were subjected to standard housing (SH) for 6 weeks, environmental enrichment (EE) for 6 weeks, or enrichment removal (ER), consisting of 4 weeks of EE followed by 2 weeks of removal into impoverished conditions (n=10/pool/group). Rats were then perfused and micropunches were collected from the basolateral amygdala (BLA) for bulk RNA-seq.

2022-07-15 | GSE208028 | GEO

Molecular Neurobiology of Loss Part 1

Project description:Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings of loss are poorly understood, making it challenging to develop treatment strategies. Here, we investigate the mechanisms of loss using an enrichment removal (ER) paradigm in rats. RNA-seq was used to investigate the molecular landscape of the basolateral amygdala (BLA), a region previously implicated in loss, in adult male Sprague-Dawley rats following ER. Rats were subjected to standard housing (SH) for 6 weeks, environmental enrichment (EE) for 6 weeks, or enrichment removal (ER), consisting of 4 weeks of EE followed by 2 weeks of removal into impoverished conditions (n=6/group). Rats were then perfused and micropunches were collected from the basolateral amygdala (BLA) for bulk RNA-seq.

2022-07-15 | GSE208026 | GEO

A Circult Mechanism for Differentiating Positive and Negative Associations

2015-02-27 | E-GEOD-66345 | biostudies-arrayexpress

Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity

Project description:The amygdala is known to modulate hippocampal synaptic plasticity. One role could be an immediate effect of basolateral amygdala (BLA) in priming synaptic plasticity in the hippocampus. Another role could be through associative synaptic co-operation and competition that triggers events involved in the maintenance of synaptic potentiation. We present evidence that the timing and activity level of BLA stimulation are important factors for the induction and maintenance of long-term potentiation (LTP) in ventral hippocampal area CA1. A 100 Hz BLA co-stimulation facilitated the induction of LTP, whereas 200 Hz co-stimulation attenuated induction. A 100 Hz BLA co-stimulation also caused enhanced persistence, sufficient to prevent synaptic competition. This maintenance effect is likely through translational mechanisms, as mRNA expression of primary response genes was unaffected, whereas protein level of plasticity-related products was increased. Further understanding of the neural mechanisms of amygdala modulation on hippocampus could provide insights into the mechanisms of emotional disorders.

2022-03-03 | GSE197708 | GEO

Transcription profiling of Arabidopsis Bla-1/Hh-0 hybrids, and Mir-0/Se-0 hybrids and their parents grown at 16C in long day conditions

Project description:Bla-1, Hh-0 and their F1 hybrid, and Mir-0, Se-0 and their F1 hybrid were grown for 3 weeks at 16 degreC long days. Whole rosettes were harvested and pooled 8-10 per sample.

2007-07-11 | E-ATMX-27 | biostudies-arrayexpress

The gastrin-releasing peptide regulates stress-enhanced fear and dopamine signaling

Project description:Fear extinction is an adaptive behavioral process critical for organism’s survival, but deficiency in extinction may lead to PTSD. While the amygdala and its neural circuits are critical for fear extinction, the molecular identity and organizational logic of cell types that lie at the core of these circuits remain unclear. Here we report that mice deficient for amygdala-enriched gastrin-releasing peptide gene (Grp-/-) exhibit enhanced neuronal activity in the basolateral amygdala (BLA) and stronger fear conditioning, as well as deficient extinction in stress-enhanced fear learning (SEFL). rAAV2-retro-based tracing combined with visualization of the GFP knocked in the Grp gene showed that BLA receives several GRPergic conditioned stimulus projections: from the indirect auditory thalamus-to-auditory cortex pathway, medial prefrontal cortex, ventral hippocampus and ventral tegmental area. Transcription of dopamine-related genes was decreased in BLA of Grp-/- mice following SEFL extinction recall, suggesting that the GRP may mediate fear extinction regulation by dopamine.

2021-12-01 | GSE164226 | GEO

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