The dual role of Irf1 in maintaining epithelial identity while enabling EMT [mRNA-seq]

ABSTRACT: To investigate the context-dependent function of Irf1 in maintaining epithelial identity while enabling TGFbeta-induced EMT in NMuMG/E9 cells, we downregulated Irf1 by siRNA and analyzed differentially regulated genes and pathways upon EMT induction (2 days TGFbeta) or in the absence of EMT (0 day TGFbeta). Intersection with Irf1 ChIP-sequencing after 2 days of TGFbeta treatment or in untreated cells revealed genes that are directly regulated by Irf1 and that could contribute to the dual role of Irf1 in EMT.

ORGANISM(S): Mus musculus

PROVIDER: GSE141500 | GEO | 2022/03/18

REPOSITORIES: GEO