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Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE141534 | GEO | 2020/05/14

REPOSITORIES: GEO

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Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance (NODSCID)

Project description:Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiology and outcome. However, predictive factors within distinct subgroups still need to be uncovered. Using multiplex immunofluorescent staining and singe-cell RNA sequencing we unraveled distinct compositions of the immunological tumor microenvironment (TME) across ATRT subgroups. CD68+ cells predominantly infiltrate ATRT-SHH and ATRT-MYC and are a negative prognostic factor for patients’ survival. Within the murine ATRT-MYC and ATRT-SHH TME, Cd68+ macrophages are core to intercellular communication with tumor cells. In ATRT-MYC distinct tumor cell phenotypes express macrophage marker genes. These cells are involved in the acquisition of chemotherapy resistance in our relapse xenograft mouse model. In conclusion, the tumor cell-macrophage interaction contributes to ATRT-MYC heterogeneity and tumor recurrence.

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Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance

Project description:Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance

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Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance (NODSCID)

Project description:Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance (NODSCID)

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