Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

ABSTRACT: Experimental ocular hypertension (IOP) induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. An established transgenic p16-3MR mouse model in which the systemic administration of the small molecule ganciclovir (GCV) selectively kills p16INK4a-expressing cells was used to compare transcriptomes of retinas from IOP and control eyes in GCV-treated and non-treated mice, to investigate how experimental removal of senescent p16INK4a-positive cells impacts retinal cells in conditions resembling glaucoma.

ORGANISM(S): Mus musculus

PROVIDER: GSE141725 | GEO | 2020/12/01

REPOSITORIES: GEO