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Next Generation Sequencing Facilitates Quantitative Analysis of control and MILIP Knockdown by siRNA in A549 human lung cancer cell line

ABSTRACT: Enriched p53 signalling after MILIP knockdown was validated by RNA-seq; A c-myc reponsive lncRNA MILIP is commonly upregulated in diverse cancer types. RNA-seq analysis of A549 cells following MILIP knockdown revealed that p53 signalling was the mostly enriched gene pathway, suggesting c-Myc may inactivate p53 through MILIP in cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141886 | GEO | 2020/08/19

REPOSITORIES: GEO

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