Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.

ABSTRACT: The Tongmai Yangxin Pill (TMYX), a patented medicine, has been widely used to treat coronary heart disease (CHD) in China for several decades. Though the anti-inflammatory effect has been preliminarily proposed as one of the potential mechanisms of TMYX for CHD treatment, the underlying mechanisms remain elusive. We used microarrays to explain the genomic changes of Tongmai Yangxin Pills in the treatment of patients with coronary heart disease, in order to explore the potential mechanism of TCM in the treatment of diseases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142008 | GEO | 2020/10/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data of 8 healthy people and 8 patients with coronary heart disease before and after 8 weeks treatment with Danlou tablets

Project description:The Danlou Tablets (DLT), a patented medicine, has been widely used to treat coronary heart disease (CHD) in China for several decades. Though the anti-inflammatory and anti-oxidation effect has been preliminarily proposed as one of the potential mechanisms of DLT for CHD treatment, the underlying mechanisms remain elusive. We use microarray to explain the genome changes of patients with coronary heart disease and patients with coronary heart disease after treatment with Danlou tablets, so as to explore the potential mechanism of treating diseases with traditional Chinese medicine.

2023-06-14 | GSE179789 | GEO

Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.

Project description:Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.

| PRJNA595589 | ENA

Analysis of components of Buxuetongluo Pills by LC-MS/MS

Project description:Buxue tongluo Pills(BTP) are a pill commonly used to treat osteonecrosis of the femoral head, but its composition and mechanism are unclear. As a result, we analyzed the components of BTP by LC-MS/MS.

2022-02-17 | PXD027269 | Pride

LncRNA microarray analysis of coronary heart disease (CHD)

Project description:The present study aims to explore the expression profiles and biological functions of long-chain noncoding RNA (lncRNA) in coronary heart disease (CHD)

2021-03-21 | GSE169256 | GEO

LncRNA microarray analysis of coronary heart disease (CHD)

Project description:LncRNA microarray analysis of coronary heart disease (CHD)

| PRJNA715910 | ENA

Health Information Technology (HIT) Enhanced Family History Documentation and Management in Primary Care

Project description:We evaluated whether collection of risk factors to generate an electronic health record (EHR)-linked personalized health risk appraisal (HRA) for coronary heart disease (CHD), diabetes, breast and colorectal cancer (CRC) was associated with improved patient-provider communication, risk assessment, and breast cancer screening plans in the next year.

| 2115439 | ecrin-mdr-crc

Expression data from human abdominal, subcutaneous adipose tissue

Project description:FCHL is a common, complex genetic lipid disorder with a largely unknown aetiology. Altered adipose tissue metabolism has been implicated as contributing to FCHL. We used microarrays to investigate the mRNA profiles of FCHL patients with CHD and non-FCHL patients with CHD in comparison with non-FCHL, non-CHD patients to define a core set of genes that were differentially expressed in FCHL and to provide a reasonable launch-pad for examining the direct contribution of one of this gene set to the development of adipose tissue. Adipose tissue was obtained from the same anatomical site - the subcutaneous, upper abdominal region - of white British males, either at coronary artery bypass surgery (designated as: FCHL-CHD (13 individuals, subdivided on TG response to statins into Group 1 (n=4), Group 2 (n=7) and unclassified (n=2)) and non-FCHL-CHD patients (6 individuals)), or at heart valve replacement: non-FCHL, non-CHD subjects (5 individuals; controls).

2013-10-29 | E-GEOD-51625 | biostudies-arrayexpress

Expression data from murine cardiac tissue

Project description:Gender dimorphism exists in the physiological response to diet and other environmental factors. Trans-hydrogenated fatty acid (TFA) intake is associated with an increase in coronary heart disease (CHD), and gender differences in the incidence of CHD are well documented. Neonatal administration of Monosodium Glutamate (MSG) causes stunted heart growth and hypoplasticity; and gender dimorphism at the growth hormone axis has been demonstrated in MSG-treated rodents. The identification of gender dimorphism in cardiac nutrigenomics may provide the basis for gender-specific medicine in the future. We used microarray analysis to examine changes in cardiac gene transcription in response to TFA and/or MSG feeding in male and female C57Bl/6J mice.

2011-12-31 | GSE22881 | GEO

Metabolic stress and therapeutic response in heart failure associated with congenital heart disease

Project description:Heart failure in congenital heart disease (CHD) has no effective treatment besides heart transplantation. While hemodynamic etiology is suggested, here we show hypoplastic left heart syndrome (HLHS), a severe CHD is a mitochondrial disease from analysis of HLHS mice and patient derived induced pluripotent stem cell cardiomyocytes (iPSC-CM). The iPSC-CM from patients suffering heart failure or death, but not those with long-term survival, showed reduced cell proliferation with increased apoptosis, mitochondrial hyperfusion with respiration defect and redox stress. Single cell sequencing showed protein synthesis overload with unfolded protein response. Drugs targeting the mitochondria restored metabolic function and rescued cell proliferation and apoptosis, suggesting new stragegies for heart failure therapy in CHD.

2022-04-07 | GSE146341 | GEO

Expression data from whole blood sample of eight kinds of TCM syndromes of rheumatoid arthritis patients.

Project description:To explore the biological connotation of eight syndromes of Rheumatoid Arthritis (RA) from the syndrome-symptom association network, and the relationship between the clinical characteristics of various syndromes and their key network target genes and pathways, which may offer clinicians auxiliary tools for diagnosis and treatment of RA patients with various traditional Chinese medicine (TCM) syndromes and promoting the developments of TCM Syndrome Theory. We used microarrays to detail the biological connotation of five syndromes (D-H, N) of Rheumatoid Arthritis (RA) and identified distinct classes of up-regulated and down-regulated genes during this process.

2023-01-01 | GSE205962 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data