Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse II

ABSTRACT: The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.

ORGANISM(S): Mus musculus

PROVIDER: GSE142027 | GEO | 2019/12/14

REPOSITORIES: GEO