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25-hydroxycholesterol effects on human hepatocyte metabolism and the antiviral state it conveys against the HCV

ABSTRACT: Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to result in an antiviral state within the host cell. Transcriptome profiling was also conducted on Huh-7 human hepatoma cells bearing subgenomic HCV replicons with and without treatment with 25-hydroxycholesterol (25-HC), an inhibitor of the mevalonate pathway that alters lipid metabolism, to assess metabolic determinants of pro- and antiviral states within the host cell. Keywords: treatment and time course

ORGANISM(S): Homo sapiens

PROVIDER: GSE14204 | GEO | 2008/12/25

SECONDARY ACCESSION(S): PRJNA111329

REPOSITORIES: GEO

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Transcription profiling of human hepatocytes treated with 25-hydroxycholesterol and the antiviral state it conveys against the HCV

Project description:Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to result in an antiviral state within the host cell. Transcriptome profiling was also conducted on Huh-7 human hepatoma cells bearing subgenomic HCV replicons with and without treatment with 25-hydroxycholesterol (25-HC), an inhibitor of the mevalonate pathway that alters lipid metabolism, to assess metabolic determinants of pro- and antiviral states within the host cell. Experiment Overall Design: compound treatment and time course

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