Multiplexed single-cell autism modeling reveals convergent mechanisms altering neuronal differentiation

ABSTRACT: We coupled dCas9-based transcriptional repression of autism and neurodevelopmental disease genes to single-cell RNA-sequencing in the context of human neuron differentiation to identify the unique and shared consequences of these perturbations in a pooled experimental format.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142078 | GEO | 2020/06/20

REPOSITORIES: GEO