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Analysis of Nucleolin and PTBP1 RNA targets before after Sciatic nerve injury

ABSTRACT: We previously showed that importin beta1 local translation in injured axons is a key event in injury-signaling and regeneration (Perry et al., 2012). Next, we showed that importin beta1 is localize to axons through a localization motif in its 3'UTR and that this motif is bound by the RNA binding proteins Nucleolin and PTBP1. In this study, we asked which other RNA targets are bound by these two RNA binding proteins in naive Sciatic nerves and how are they changing 7 days after injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE142107 | GEO | 2021/07/23

REPOSITORIES: GEO

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