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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation III]

ABSTRACT: In-silico analysis to identify molecular signature of liver sinusoidal endothelial cells in comparison to other endohtelial cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE142224 | GEO | 2020/10/25

REPOSITORIES: GEO

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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation II]

Project description:In human F8 deficiency leads to hemophilia A and is largely synthesized and secreted by the sinusoidal endothelial cells of the liver (LSECs). However, the specificity and characteristics of these cells is not well known. In this study, we performed genome wide expression and CpG methylation profiling of fetal and adult human LSECs together with other fetal endothelial cells, from lung (micro-vascular and arterial), and heart (micro-vascular). Our results reveal plenty of expression and methylation markers distinguishing LSECs at both fetal and adult stages. Differential gene expression of fetal LSECs in comparison to other fetal endothelial cells pointed to several differential regulated pathways and functions in fetal LSECs. We used targeted bisulfite re-sequencing to confirm selected top differentially methylated regions. We further designed an assay where we used the selected methylation markers to test the degree of similarity of in house iPSs generated vascular endothelial cells to fetal and adult LSECs; a higher similarity was found to the fetal than to adult LSECs. Our molecular profiling study provides a guide to test the effectiveness of production of in vitro differentiated LSECs that could be used in cellular therapies. In-silico analysis to identify molecular signature of liver sinusoidal endothelial cells in comparison to other endohtelial cells

2020-10-25 | GSE140295 | GEO

Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation I]

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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation III]

Project description:Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation III]

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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation II]

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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [expression array]

Project description:Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [expression array]

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Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation I]

Project description:Molecular atlas of fetal and adult human liver sinusoidal endothelial cells: a F8 secreting cell [methylation I]

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Normal and injured liver sinusoidal endothelial cells

Project description:Comparison of C57BL/6J 8-10 weeks male mouse liver sinusoidal endothelial cells (LSEC) from normal liver and from liver injured by carbon tetrachloride administration. Keywords: other

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Comparison of gene expression between Human umbilical vein endothelial cells and Human liver sinusoidal endothelial cells

Project description:To identify leukocyte adhesion receptors which differentially regulate recruitment in human liver sinusoidal endothelial cells compared to a protoptypic venular endothelium Gene expression was measured in four groups Group 1: cultured human liver sinusoidal endothelial cells (HSEC) Group 2: cultured human umbilical vein endothelial cells (HUVEC) Group3: Interferon gamma and tumour necrosisfactor alpha treated HSEC and Group 4: Interferon gamma and tumour necrosisfactor alpha treated HUVEC. Two replicates were used for each group.

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