DM-tRNA-seq of mock and MHV68-infected mouse MC57G fibroblasts

ABSTRACT: We applied a tRNA-specific sequencing pipeline to analyze tRNA expression during infection of MC57G fibroblasts with the gammaherpesvirus MHV68. We find that expression of 14% of tRNA genes is significantly upregulated during infection. By mapping reads to either premature tRNA (pre-tRNA) or mature tRNA sequences, we find that increased expression of tRNA genes is manifested at the level of the pre-tRNA only, indicating a homeostatic mechanism to maintain the size and composition of mature tRNA pools.

ORGANISM(S): Mus musculus

PROVIDER: GSE142393 | GEO | 2019/12/20

REPOSITORIES: GEO