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The postprandial transcriptomic response of adipose tissue to high fat meals in middle-aged men with metabolic syndrome

ABSTRACT: This study aimed to examine the postprandial transcriptome of adipose tissue middle-aged men selectively recruited on the basis of MetS (defined by the International Diabetes Federation (IDF) criteria) and healthy control participants. Two breakfast meals that provided different macronutrient composition, and were indicative of major patterns of dietary habits (animal-based versus plant-based) were given, postprandial adipose gene expression was measured by microarray at fasting (0 h) and 4 hours post-meal.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142401 | GEO | 2020/12/01

REPOSITORIES: GEO

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Polyunsaturated fatty acids acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increases postprandial insulin sensitivity

Project description:Dietary fat quality may influence skeletal muscle lipid handling and fat accumulation, thereby modulating insulin sensitivity. Objective: To examine acute effects of meals with various fatty acid (FA) compositions on skeletal muscle FA handling and postprandial insulin sensitivity in obese insulin resistant men. Design: In a single-blinded randomized crossover study, 10 insulin resistant men consumed three high-fat mixed-meals (2.6MJ). Meals were high in saturated FA (SFA), in monounsaturated FA (MUFA) or in polyunsaturated FA (PUFA). Fasting and postprandial skeletal muscle FA handling were examined by measuring arterio-venous concentration differences across forearm muscle. [2H2]-palmitate was infused intravenously to label endogenous triacylglycerol (TAG) and FFA in the circulation and [U-13C]-palmitate was added to the meal to label chylomicron-TAG. Skeletal muscle biopsies were taken to assess intramuscular lipid metabolism and gene expression. Results: Insulin and glucose responses (AUC) after SFA meal were significantly higher compared with PUFA meal (p=0.003 and 0.028, respectively). Uptake of TAG-derived FA was significantly lower in the early postprandial phase after PUFA meal as compared with other meals (AUC60-120, p<0.001). The PUFA meal induced less transcriptional downregulation of oxidative pathways compared with other meals. The fractional synthetic rate was higher in DAG and PL fraction after MUFA and PUFA meal. Conclusion: Intake of a PUFA meal reduced TAG-derived skeletal muscle FA uptake, which was accompanied by higher postprandial insulin sensitivity and a tendency towards a higher muscle lipid turnover. These data suggest that the effects of replacement of SFA by PUFA may contribute to less muscle lipid uptake and may be therefore protective against the development of insulin resistance. Keywords: expression profiling by array randomized crossover dietary intervention study

2012-02-21 | E-GEOD-31901 | biostudies-arrayexpress

Polyunsaturated fatty acids acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increases postprandial insulin sensitivity

2012-02-21 | GSE31901 | GEO

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Transcription profiling of human leukocytes to measure the postprandial effect of an oat bran meal on heathy subjects

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2010-07-01 | E-MEXP-2261 | biostudies-arrayexpress

The postprandial transcriptomic response of adipose tissue to high fat meals in middle-aged men with metabolic syndrome

Project description:The postprandial transcriptomic response of adipose tissue to high fat meals in middle-aged men with metabolic syndrome

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Project description:Evaluate differences in gene methylation levels between obese men with and without the metabolic syndrome Visceral adipose tissue from obese men with the metabolic syndrome (MetS+, N=7) vs. obese men without the metabolic syndrome (MetS-, N=7)

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laughter regulates postprandial blood glucose levels and gene expression

Project description:Sample tissue: peripheral blood Disease: diabetes Samples for gene expression analysis were obtained before the meal and 1.5 hours after the event. Event: listening to a Japanese comic story or a monotonous academic lecture without humor. Keywords: equivalent probe

2004-10-21 | GSE1322 | GEO

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NCBI GEO Submission of human whole blood transcriptomes in response to a high-fat meal

Project description:Modern humans spend most of their time having eaten recently. The purpose of the current project is to understand how the blood, which contains immune cells, responds in the hours after eating a meal that is moderately high in fat. We used a sequencing method to observe the expression of all the genes in blood cells in five participants who were each fed a high fat meal on three separate days. The results are reported in the manuscript, “Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal."

2019-03-01 | GSE127530 | GEO

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