Interleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling

ABSTRACT: RNA sequencing of primary human aortic or arterial VSMCs after stimulation with transforming growth factor beta-1 (TGFβ1) revealed marked IL11 upregulation. In vitro, IL11 stimulation of VSMCs resulted in phenotypic switching by increased ECM production and migration/invasion. Neutralizing IL11 antibody treatment abolished phenotypic switching in VSMCs. IL11 plays an important and non-redundant role in VSMC phenotypic switching.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142417 | GEO | 2020/10/20

REPOSITORIES: GEO