Adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation

ABSTRACT: Beta-adrenergic stimulation stabilizes ERK3, resulting in the formation of a complex with MK5 and thereby driving lipolysis. A downstream target of the complex is FOXO1, which controls expression of the lipolytic enzyme ATGL. Deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation.

ORGANISM(S): Mus musculus

PROVIDER: GSE142424 | GEO | 2021/01/01

REPOSITORIES: GEO