Genes regulated by COUP-TFII inhibitor

ABSTRACT: The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases including prostate cancer, heart failure and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it an intriguing therapeutic target. Here, we identified a potent and specific COUP-TFII inhibitor through high-throughput screening. The inhibitor specifically suppressed COUP-TFII activity to regulate its target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142475 | GEO | 2020/05/12

REPOSITORIES: GEO