Therapeutic IDOL reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice

ABSTRACT: An antisense oligonucleotide (ASO) against E3 ubiquitin ligase IDOL in the brain significantly decreased Aβ pathology, and improved spatial learning and memory in APP/PS1 mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE142535 | GEO | 2019/12/24

REPOSITORIES: GEO