Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cocaine-mediated circadian reprogramming in the striatum through a dopamine D2 receptor-PPARg circuit

ABSTRACT: Cocaine-dependent genome-wide effects were analyzed, total RNAs were extracted from ventral striatum tissue punches and processed for RNA-seq analyses.

ORGANISM(S): Mus musculus

PROVIDER: GSE142657 | GEO | 2020/07/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Cocaine-mediated circadian reprogramming in the striatum through a dopamine D2 receptor-PPARg circuit

Project description:Cocaine-mediated circadian reprogramming in the striatum through a dopamine D2 receptor-PPARg circuit

| PRJNA597882 | ENA

Cocaine Induces Differential Circular RNAs Expression in Striatum

Project description:Circular RNA (circRNA) has recently emerged as a novel type of endogenous non-coding RNA. It plays natural microRNA sponge effect that represses the activity of corresponding miRNAs by binding with them, thus regulating gene expression. Recent studies demonstrate that circRNAs are significantly enriched in the brain and a disproportionate fraction of them is derived from host genes that code for synaptic proteins. In addition, studies have shown that microRNAs are involved in synaptic plasticity, memory formation and cocaine addiction. However, the role of circRNAs in cocaine reward is largely unknown. This study aimed to identify the expression profile of circRNAs in the striatum of mice after cocaine self-administration by using circRNA microarray analysis.

2020-04-01 | GSE112370 | GEO

Tolerance to cocaine-induced motor effects in rats: transcriptomic regulations in the dorsal striatum

Project description:Comparison of gene expression in the dorsal striatum of rats after chronic binge or acute binge cocaine injections or saline treatment

2020-11-12 | GSE134154 | GEO

Tolerance to cocaine-induced motor effects in rats: transcriptomic regulations in the ventral striatum

Project description:Comparison of gene expression in the dorsal striatum of rats after chronic binge or acute binge cocaine injections or saline treatment

2020-11-12 | GSE134107 | GEO

RNA-sequencing of dorsomedial striaum in male Drd2 flox/flox (WT) and Drd2 flox/flox ChAT-Cre+/- (ChI-D2RKO) mice treated with saline or 20 mg/kg of cocaine (ip) 1 hour prior to dissection

Project description:Mice were placed in a novel home cage and habituated for 2 hours. They were then injected with saline or cocaine (20 mg/kg ip). After 1 hour, mice were rapidly sacrificed via cervical dislocation, their brains were promptly dissected, and were rapidly frozen in 2-methylbutane. Tissue punches from the dorsomedial striatum were taken and RNA was isolated using Trizol following the manufactures recommendations.

2020-04-22 | E-MTAB-8589 | biostudies-arrayexpress

Cocaine Induces Differential Circular RNAs Expression in Striatum

Project description:Cocaine Induces Differential Circular RNAs Expression in Striatum

| PRJNA445834 | ENA

Tolerance to cocaine-induced motor effects in rats: transcriptomic regulations in the ventral striatum

Project description:Tolerance to cocaine-induced motor effects in rats: transcriptomic regulations in the ventral striatum

| PRJNA553786 | ENA

circRNAs in the mouse nucleus accumbens (ventral striatum) after cocaine conditioned place preference (CPP)

Project description:circRNAs in the mouse nucleus accumbens (ventral striatum) after cocaine conditioned place preference (CPP)

| PRJNA642165 | ENA

Reactive Oxygen Species Mediate Transcriptional Responses to Dopamine and Cocaine in Human Cerebral Organoids [Rudibaugh2023]

Project description:Dopamine signaling in the adult ventral forebrain regulates behavior, stress response, and memory formation and in neurodevelopment regulates neural differentiation and cell migration. Excessive dopamine levels including due to cocaine use both in utero and in adults could lead to long-term adverse consequences. The mechanisms underlying both homeostatic and pathological changes remain unclear, partly due to the diverse cellular responses elicited by dopamine and the reliance on animal models that exhibit species-specific differences in dopamine signaling. To address these limitations, 3-D cerebral organoids have emerged as human-derived models, recapitulating salient features of human cell signaling and neurodevelopment. Organoids have demonstrated responsiveness to external stimuli, including substances of abuse, making them valuable investigative models. In this study we utilize the Xiang-Tanaka ventral forebrain organoid model and characterize their response to acute and chronic dopamine or cocaine exposure. The findings revealed a robust immune response, novel response pathways, and a potential critical role for reactive oxygen species (ROS) in the developing ventral forebrain. These results highlight the potential of cerebral organoids as in vitro human models for studying complex biological processes in the brain.

2023-08-07 | GSE234767 | GEO

Reactive Oxygen Species Mediate Transcriptional Responses to Dopamine and Cocaine in Human Cerebral Organoids [Rudibaugh2022]

2023-08-07 | GSE234766 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data