Transcriptomic analysis by RNA-seq unveils distinct gene expression profile of U397 cells depleted of NSPs

ABSTRACT: Characterization of transcriptomic changes associated with genetic ablation of three neutrophil serine proteases (CTSG, ELANE, PRTN3). U937 cells depleted of CTSG, ELANE, and PRTN3 simultaneously (ΔNSPs) were generated using the CRISPR-Cas9 system and sgRNAs. RNA-Seq analysis revealed transcriptomic changes between control cells and ΔNSPs, with 170 and 220 genes up- or down-regulated respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142662 | GEO | 2021/04/02

REPOSITORIES: GEO