Extensive DNA methylation variation across a single ADPKD kidney

ABSTRACT: We have previously described global hypomethylation and site-specific DNA methylation changes which are associated with disease-state renal tissue in Autosomal Dominant Polycystic Kidney Disease (ADPKD). However, to-date there are no available data on the pattern of DNA methylation across an ADPKD kidney. Here we describe the methylome of eight individual cysts from a single ADPKD patient and peform an intra-individual analysis to identify regions of DNA methylation variability.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142664 | GEO | 2020/01/14

REPOSITORIES: GEO