Gene expression analysis of anti-tuberculous drug responses in a whole blood transcriptome model

ABSTRACT: There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approach might additionally reveal mechanisms of response. Microarray analysis was performed on Mycobacterium tuberculosis (Mtb) RNA extracted from whole blood cultures, sputum from TB patients on combination treatment, and drug-free broth cultures

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE142756 | GEO | 2020/03/23

REPOSITORIES: GEO