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RNA sequencing of porcine smooth muscle cells, after treatments with platelet derived growth factor and S100A4 protein

ABSTRACT: Smooth muscle cells were treated with platelet derived growth factor (PDGF-BB) and S100A4 protein to decipher the mechanisms by which they contribute to smooth muscle cell phenotypic transition. We report that PDGF-BB treatment upregulates genes related to growth response or to extracellular matrix component proteases, while S100A4 upregulates pro-inflammatory genes. When used in combination, PDGF-BB and S100A4 show synergistic action by enhancing the upregulation of genes already affected by S100A4 and by inducing the upregulation of genes exclusive for this condition.

ORGANISM(S): Sus scrofa

PROVIDER: GSE143296 | GEO | 2022/01/20

REPOSITORIES: GEO

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