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BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression

ABSTRACT: There is limited research on which specific Wnt targets are regulated by B-Cell Lymphoma-9 (BCL9) and whether BCL9 regulates other signaling pathways to drive cancer malignancy. Here, using ChIP-Exo we have demonstrated that BCL9 in a protein complex with STAT3 drives DCIS invasive progression by regulation of enhancers and enhancer associated target genes involved in cellular growth, invasion and migration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143313 | GEO | 2020/01/09

REPOSITORIES: GEO

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BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression

Project description:BCL9/STAT3 Regulation of Transcriptional Enhancer Networks Promote DCIS Progression

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Project description:cDNA aCGH study of pure DCIS (breast duct carcinoma in situ) without invasive tumor, DCIS associated with IDC (breast invasive duct carcinoma) and its IDC component 23 patients: 6 pure DCIS without invasive cancer and no history of invasive cancer, 17 DCIS associated with IDC. Out of the latter 1 tumor had only enough DCIS (#16) for aCGH and one - IDC (#23) Keywords: Comparative clinical study

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